The HALT-IT trial is assessing whether early administration of tranexamic acid in people with acute gastrointestinal bleeding can reduce their risk of dying in the hospital. The trial is also measuring the effects of the treatment on re-bleeding, non-fatal vascular events, blood transfusion, surgical intervention and general health status. The HALT-IT trial began recruitment on 4 July 2013 and is aiming to recruit 12,000 patients from hospitals worldwide by 31 May 2019.

Gastrointestinal bleeding is a common emergency with a 10-15% death rate. An effective treatment could save thousands of lives worldwide, In the CRASH-2 trial, we showed that, if given within 1 hour, tranexamic acid reduces mortality in bleeding trauma patients. Specifically, tranexamic acid reduces the risk of bleeding to death by about one third, with no increase in side effects. If tranexamic acid was shown to have similar effects in gastrointestinal bleeding, this would be a major advance.

12,000 patients randomised 
(last updated 21/06/2019
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  • Our Pakistan newsletter for May 2019 is now available online. Thank you to everyone for their tremendous help in randomising over 4,200 from Pakistan.

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  • Our Summer 2018 Newsletter is now available online. Congratulations to all our collaborators for their hard work in randomising over 9000 patients.

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  • Professor Muttiullah Khan, Head of Department at Unit II Holy Family Hospital Rawalpindi & National Coordinator in Pakistan had some fantastic comments to share with the HALT-IT team. Please read in full in our January Newsletter.

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  • Our first Newsletter of 2017 - A huge thank to all for randomising over 6000 patients.

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  • Please check current newsletters for any updates, news and collaborators contributions.

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